Nearly 1,200 patients in Canada
received lower doses of their cancer drugs as a result of poor communication
between a compounding pharmacy supplier and several hospitals that utilized the
service. The drugs were cyclophosphamide and gemcitabine, used as part of a
regimen for breast and lung cancer as well as lymphoma and leukemia. Patients
received watered down doses for about a year without anyone realizing there was
more saline solution in the bags than stated on the label. Finally, a pharmacy
technician at one of the hospitals noticed more fluid in the bags than expected
and brought it to the attention of others.
When preparing chemotherapy, cancer drugs are added to ready-to-use intravenous fluid bags from a manufacturer, but the bags typically hold a greater volume of diluent than stated on the label, a situation known as “overfill.” Overfill takes into account that some evaporation might occur from the plastic bags and also that some fluid will be left in IV tubing after injection. Additional fluid is also added to the individual cancer drug vials to make a solution out of the powder inside before adding them to the bag.
About a year ago, the hospitals stopped outsourcing chemotherapy preparation from a pharmacy they’d worked with previously and contracted with a new provider. In this recent incident, the new pharmacy labeled the product differently than in the past.Looking for a agatebeads? The total amount of drug in the bag was labeled correctly but the final drug concentration listed on the label did not take overfill into account.
The bags actually contained several doses of medication that the hospital used to prepare chemotherapy for different patients. What they didn’t know was the drugs were from 3% to 20% more diluted than labeled. The failure to understand the final concentration resulted in hospital staff withdrawing less fluid, and therefore less of the cancer drug from the bags than was actually needed for each dose. Thus, some patients received a lower drug amount than intended.
All of the patients have been informed by the hospitals.Sale cheap bridalgown online, white, black, berry, Graphite canada goose victoria parka hot sale. Management of any overfill volume is perceived to be more critical for oncology medications because the dosing of these drugs is specific to each individual patient and the type of cancer being treated. Although the overall impact is unclear, one can only imagine how distressed the patients and families must be. Most cancer experts do not believe the medication error will have any adverse effects on their overall treatment.
In the US, hospitals and clinics that care for cancer patients generally prepare their own chemotherapy doses and don’t use multiple dose source containers of chemotherapy from an outside pharmacy. However, overfill is still an issue even when bags contain a single dose. In the US, most hospitals simply label the bags with the amount of drug added and the total volume (including estimated overfill).Shop for high quality laceweddingveils dress products ! So nurses know exactly how much to infuse to get the whole dose in.
She entered politics during General Zia ul-Haq's dictatorship through the women's rights protest movement. She has twice been elected to the National Assembly on women's reserve seats, but says contesting a direct With cute cheap designerbeadedeveninggowns.seat remains an insurmountable challenge for many women. "People ask me why I don't go into general elections. It's just practically not possible for me. I have only one brother, who lives abroad. You've got to have brothers, cousins, uncles – we're a very male-dominated society."
Like Wazir Ali, most women in parliament entered through reserved quota seats. Their presence has had a big impact on legislation. Over the last term, a women's parliamentary caucus was formed, and a raft of pro-women laws introduced, criminalising forced marriage, acid crimes, and sexual harassment in the workplace. "A significant proportion of the business of the House, sometimes a majority, has been moved by women," says Wazir Ali. "Some men are prejudiced, but Pakistan's political context is changing."
When preparing chemotherapy, cancer drugs are added to ready-to-use intravenous fluid bags from a manufacturer, but the bags typically hold a greater volume of diluent than stated on the label, a situation known as “overfill.” Overfill takes into account that some evaporation might occur from the plastic bags and also that some fluid will be left in IV tubing after injection. Additional fluid is also added to the individual cancer drug vials to make a solution out of the powder inside before adding them to the bag.
About a year ago, the hospitals stopped outsourcing chemotherapy preparation from a pharmacy they’d worked with previously and contracted with a new provider. In this recent incident, the new pharmacy labeled the product differently than in the past.Looking for a agatebeads? The total amount of drug in the bag was labeled correctly but the final drug concentration listed on the label did not take overfill into account.
The bags actually contained several doses of medication that the hospital used to prepare chemotherapy for different patients. What they didn’t know was the drugs were from 3% to 20% more diluted than labeled. The failure to understand the final concentration resulted in hospital staff withdrawing less fluid, and therefore less of the cancer drug from the bags than was actually needed for each dose. Thus, some patients received a lower drug amount than intended.
All of the patients have been informed by the hospitals.Sale cheap bridalgown online, white, black, berry, Graphite canada goose victoria parka hot sale. Management of any overfill volume is perceived to be more critical for oncology medications because the dosing of these drugs is specific to each individual patient and the type of cancer being treated. Although the overall impact is unclear, one can only imagine how distressed the patients and families must be. Most cancer experts do not believe the medication error will have any adverse effects on their overall treatment.
In the US, hospitals and clinics that care for cancer patients generally prepare their own chemotherapy doses and don’t use multiple dose source containers of chemotherapy from an outside pharmacy. However, overfill is still an issue even when bags contain a single dose. In the US, most hospitals simply label the bags with the amount of drug added and the total volume (including estimated overfill).Shop for high quality laceweddingveils dress products ! So nurses know exactly how much to infuse to get the whole dose in.
She entered politics during General Zia ul-Haq's dictatorship through the women's rights protest movement. She has twice been elected to the National Assembly on women's reserve seats, but says contesting a direct With cute cheap designerbeadedeveninggowns.seat remains an insurmountable challenge for many women. "People ask me why I don't go into general elections. It's just practically not possible for me. I have only one brother, who lives abroad. You've got to have brothers, cousins, uncles – we're a very male-dominated society."
Like Wazir Ali, most women in parliament entered through reserved quota seats. Their presence has had a big impact on legislation. Over the last term, a women's parliamentary caucus was formed, and a raft of pro-women laws introduced, criminalising forced marriage, acid crimes, and sexual harassment in the workplace. "A significant proportion of the business of the House, sometimes a majority, has been moved by women," says Wazir Ali. "Some men are prejudiced, but Pakistan's political context is changing."
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